Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

A selective antibiotic for Lyme disease.

Leimer, Nadja; Wu, Xiaoqian; Imai, Yu; Morrissette, Madeleine; Pitt, Norman; Favre-Godal, Quentin; Iinishi, Akira; Jain, Samta; Caboni, Mariaelena; Leus, Inga V; Bonifay, Vincent; Niles, Samantha; Bargabos, Rachel; Ghiglieri, Meghan; Corsetti, Rachel; Krumpoch, Megan; Fox, Gabriel; Son, Sangkeun; Klepacki, Dorota; Polikanov, Yury S; Freliech, Cecily A; McCarthy, Julie E; Edmondson, Diane G; Norris, Steven J; D'Onofrio, Anthony; Hu, Linden T; Zgurskaya, Helen I; Lewis, Kim.

Cell ; 184(21): 5405-5418.e16, 2021 10 14.

Artigo em Inglês | MEDLINE | ID: mdl-34619078

2.

Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation.

Petnicki-Ocwieja, Tanja; McCarthy, Julie E; Powale, Urmila; Langston, P Kent; Helble, Jennifer D; Hu, Linden T.

PLoS Pathog ; 19(12): e1011886, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38157387

3.

An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling.

Petnicki-Ocwieja, Tanja; Sharma, Bijaya; Powale, Urmila; Pathak, Devesh; Tan, Shumin; Hu, Linden T.

Traffic ; 23(12): 558-567, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36224049

4.

The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance.

Helble, Jennifer D; McCarthy, Julie E; Sawden, Machlan; Starnbach, Michael N; Hu, Linden T.

PLoS Pathog ; 18(10): e1010903, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36265003

5.

A putative xanthine dehydrogenase is critical for Borrelia burgdorferi survival in ticks and mice.

Phelan, James P; Bourgeois, Jeffrey S; McCarthy, Julie E; Hu, Linden T.

Microbiology (Reading) ; 169(1)2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36748545

6.

Innate Immune Memory to Repeated Borrelia burgdorferi Exposure Correlates with Murine In Vivo Inflammatory Phenotypes.

Bernard, Quentin; Hu, Linden T.

J Immunol ; 205(12): 3383-3389, 2020 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-33168577

7.

Genetic Background Amplifies the Effect of Immunodeficiency in Antibiotic Efficacy Against Borrelia burgdorferi.

Sharma, Bijaya; McCarthy, Julie E; Freliech, Cecily A; Clark, Morgen M; Hu, Linden T.

J Infect Dis ; 224(2): 345-350, 2021 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-33216133

8.

Lyme Disease Pathogenesis.

Coburn, Jenifer; Garcia, Brandon; Hu, Linden T; Jewett, Mollie W; Kraiczy, Peter; Norris, Steven J; Skare, Jon.

Curr Issues Mol Biol ; 42: 473-518, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33353871

9.

Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector.

Phelan, James P; Kern, Aurelie; Ramsey, Meghan E; Lundt, Maureen E; Sharma, Bijaya; Lin, Tao; Gao, Lihui; Norris, Steven J; Hyde, Jenny A; Skare, Jon T; Hu, Linden T.

PLoS Pathog ; 15(5): e1007644, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-31086414

10.

Interactions between Borrelia burgdorferi and its hosts across the enzootic cycle.

Helble, Jennifer D; McCarthy, Julie E; Hu, Linden T.

Parasite Immunol ; 43(5): e12816, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33368329

11.

Hydrogen peroxide-producing pyruvate oxidase from Lactobacillus delbrueckii is catalytically activated by phosphotidylethanolamine.

Cornacchione, Louis P; Hu, Linden T.

BMC Microbiol ; 20(1): 128, 2020 05 24.

Artigo em Inglês | MEDLINE | ID: mdl-32448120

12.

A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species.

Ramsey, Meghan E; Hyde, Jenny A; Medina-Perez, Diana N; Lin, Tao; Gao, Lihui; Lundt, Maureen E; Li, Xin; Norris, Steven J; Skare, Jon T; Hu, Linden T.

PLoS Pathog ; 13(2): e1006225, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-28212410

13.

Interspecies Inhibition of Porphyromonas gingivalis by Yogurt-Derived Lactobacillus delbrueckii Requires Active Pyruvate Oxidase.

Cornacchione, Louis P; Klein, Brian A; Duncan, Margaret J; Hu, Linden T.

Appl Environ Microbiol ; 85(18)2019 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-31285191

14.

Identifying Vancomycin as an Effective Antibiotic for Killing Borrelia burgdorferi.

Wu, Xiaoqian; Sharma, Bijaya; Niles, Samantha; O'Connor, Kathleen; Schilling, Rebecca; Matluck, Nicole; D'Onofrio, Anthony; Hu, Linden T; Lewis, Kim.

Antimicrob Agents Chemother ; 62(11)2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30126963

15.

Using Tn-seq To Identify Pigmentation-Related Genes of Porphyromonas gingivalis: Characterization of the Role of a Putative Glycosyltransferase.

Klein, Brian A; Cornacchione, Louis P; Collins, Marisha; Malamy, Michael H; Duncan, Margaret J; Hu, Linden T.

J Bacteriol ; 199(14)2017 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-28484050

16.

Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis.

Killpack, Tess L; Ballesteros, Maria; Bunnell, Stephen C; Bedugnis, Alice; Kobzik, Lester; Hu, Linden T; Petnicki-Ocwieja, Tanja.

Infect Immun ; 85(10)2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28717031

17.

Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi.

Troy, Erin B; Lin, Tao; Gao, Lihui; Lazinski, David W; Lundt, Maureen; Camilli, Andrew; Norris, Steven J; Hu, Linden T.

Mol Microbiol ; 101(6): 1003-23, 2016 09.

Artigo em Inglês | MEDLINE | ID: mdl-27279039

18.

Adaptor Protein-3-Mediated Trafficking of TLR2 Ligands Controls Specificity of Inflammatory Responses but Not Adaptor Complex Assembly.

Petnicki-Ocwieja, Tanja; Kern, Aurelie; Killpack, Tess L; Bunnell, Stephen C; Hu, Linden T.

J Immunol ; 195(9): 4331-40, 2015 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-26423153

19.

Lyme Disease.

Hu, Linden T.

Ann Intern Med ; 164(9): ITC65-ITC80, 2016 May 03.

Artigo em Inglês | MEDLINE | ID: mdl-27136224

20.

Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.

Sanchez, Edgar; Vannier, Edouard; Wormser, Gary P; Hu, Linden T.

JAMA ; 315(16): 1767-77, 2016 Apr 26.

Artigo em Inglês | MEDLINE | ID: mdl-27115378

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